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Thursday, July 30, 2020 | History

2 edition of Structures and proton-pumping strategies of mitochondrial respiratory enzymes found in the catalog.

Structures and proton-pumping strategies of mitochondrial respiratory enzymes

Brian E. Schultz

Structures and proton-pumping strategies of mitochondrial respiratory enzymes

by Brian E. Schultz

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Published by Annual Reviews Inc. in Palo Alto .
Written in English


Edition Notes

Photocopy of: Annual review of biophysics and biomolecular structure, 30, (2001), pp.23-65.

Other titlesAnnual review of biophysics and biomolecular structure.
StatementBrian E. Schultz and Sunney I. Chan.
ID Numbers
Open LibraryOL19692802M

  Crystal structures suggest how electron transfer drives proton pumping from afar. Complex I is the first enzyme of the respiratory chain, playing .   Mitochondrial complex I by far is the largest and most complicated protein complex of the inner mitochondrial membrane catalyzing the first step of the mitochondrial respiratory chain. It has a key role in supplying the mitochondrial respiratory chain with reducing equivalents since the majority of the electrons are provided by NADH (Schultz.

Abstract. Cytochrome c oxidase (COX) is the terminal oxidase of the mitochondrial respiratory system. This enzyme reduces molecular oxygen (O 2) to water in a reaction coupled with the pumping of protons across the mitochondrial inner ss in investigating the reaction mechanism of this enzyme has been limited by the resolution of its X-ray structure.   Mammalian mitochondria use folate-bound one-carbon units generated by the enzyme SHMT2 to methylate tRNA, and this modification is required for mitochondrial .

Mitochondria produce most of the energy in animal cells by a process called oxidative phosphorylation. Electrons are passed along a series of respiratory enzyme complexes located in the inner mitochondrial membrane, and the energy released by this electron transfer is used to pump protons across the membrane. The resultant electrochemical gradient enables another complex, adenosine 5. Schultz BE, Chan SI () Structures and proton-pumping strategies of mitochondrial respiratory enzymes. Annu Rev Biophys Biomol Struct –65 PubMed Google Scholar


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Structures and proton-pumping strategies of mitochondrial respiratory enzymes by Brian E. Schultz Download PDF EPUB FB2

Enzymes of the mitochondrial respiratory chain serve as proton pumps, using the energy made available from electron transfer reactions to transport protons across the inner mitochondrial membrane and create an electrochemical gradient used for the production of ATP. The ATP synthase enzyme is reversible and can also serve as a proton pump by coupling ATP hydrolysis to proton translocation Cited by: of the respiratory enzymes uses a different strategy for performing proton pumping.

In this work, the strategies are described and the structural bases for the action of these proteins are discussed in light of recent crystal structures of several respiratory enzymes. The mechanisms and efficiency of proton translocation are also analyzed.

LITERATURE CITED. Abstract. Abstract Enzymes of the mitochondrial respiratory chain serve as proton pumps, using the energy made available from electron transfer reactions to transport protons across the inner mitochondrial membrane and create an electrochemical gradient used for the production of ATP.

The ATP synthase enzyme is reversible and can also serve as a proton pump by coupling ATP hydrolysis to proton by: Structures and Proton-Pumping Strategies of Mitochondrial Respiratory Enzymes Article Literature Review (PDF Available) in Annual Review of Biophysics and Biomolecular Structure 30(1) Structures and proton-pumping strategies of mitochondrial respiratory enzymes Schultz, Brian E.

and Chan, Sunney I. () Structures and proton-pumping strategies of mitochondrial respiratory enzymes. Annual Review of Biophysics and Biomolecular Structure, pp. ISSN   Each of the respiratory enzymes uses a different strategy for performing proton pumping. In this work, the strategies are described and the structural bases for the action of these proteins are discussed in light of recent crystal structures of several respiratory enzymes.

Fig. The Blue Book: Mitochondrial Pathways and Respiratory Control 1st edition (). 1st Mitochondrial Physiology Summer School, MiPsummer JulySchröcken, Austria.

Mitochondrial Pathways and Respiratory Control Preface The present introduction to. Mitochondrial PE increases skeletal muscle respiratory capacity.

Endurance exercise training induces a robust proliferation of skeletal muscle mitochondria to increase aerobic capacity (), but it is unknown whether training coincides with qualitative changes in mitochondrial phospholipid composition ().C57BL6/J mice were subjected to 5 weeks of graded treadmill training, which promoted.

Exercise capacity is a strong predictor of all-cause mortality. Skeletal muscle mitochondrial respiratory capacity, its biggest contributor, adapts robustly to changes in energy demands induced by contractile activity. While transcriptional regulation of mitochondrial enzymes has been extensively studied, there is limited information on how mitochondrial membrane lipids are regulated.

Schultz BE, Chan SJ () Structures and proton-pumping strategies of mitochondrial respiratory enzymes. Annu Rev Biophys Biomol Struct –65 PubMed CrossRef Google Scholar. Buy Physical Book Learn about institutional subscriptions.

Cite chapter. MECHANISM OF PROTON PUMPING IN COMPLEXES I, III, AND IV. Complex I, or NADH‐ubiquinone oxidoreductase (EC ), is the largest of the mitochondrial respiratory complexes with a size of ∼ kDa.

This complex catalyzes NADH oxidation and ubiquinone reduction and translocates four protons from the N‐side to the P‐side. Respiratory complex I is an intricate multi-subunit membrane protein with a central function in aerobic energy metabolism.

During the last years, structures of mitochondrial complex I and respiratory supercomplexes were determined by cryo-EM at increasing resolution. Even though their cellular functions are known, detailed knowledge of the biology of the mtDNA-encoded polypeptides and RNAs is limited.

To investigate structure–function relationships in these gene products, we have needed to rely upon indirect methods of analysis, such as crystallographic studies of purified mitochondrial enzymes (reviewed in Ref. 2), or inferences from genetic studies in. Each of the respiratory enzymes uses a different strategy for performing proton pumping.

In this work, the strategies are described and the structural bases for the action of these proteins are. Brian E. Schultz, Sunney I.

Chan. Structures and Proton-Pumping Strategies of Mitochondrial Respiratory Enzymes. Annual Review of Biophysics and Biomolecular Structure.

Brian E. Schultz, Sunney I. Chan. Structures and Proton-Pumping Strategies of Mitochondrial Respiratory Enzymes. Annual Review of Biophysics and Biomolecular Structure30 (1), Leonid A Sazanov, John E Walker. Oxidative phosphorylation (UK / ɒ k ˈ s ɪ d.

t ɪ v /, US / ˈ ɑː k. s ɪ ˌ d eɪ. t ɪ v / or electron transport-linked phosphorylation) is the metabolic pathway in which cells use enzymes to oxidize nutrients, thereby releasing the chemical energy of molecular oxygen, which is used to produce adenosine triphosphate (ATP). In most eukaryotes, this takes place inside mitochondria.

BCPP compounds have been developed as PET imaging probes for neurodegenerative diseases in the living brain. 18 F-BCPP-EF identifies damaged neuronal areas based on the lack of MC-I; however, its underlying mechanisms of action and specificity for MC-I remain unclear.

We herein report the effects of BCPP-BF, -EF, -EM on MC-I in respiratory chain complexes using cardiomyocyte SMP. Structures and proton-pumping strategies of mitochondrial respiratory enzymes Oxidative phosphorylation at the fin de siècle An overview of Chemiosmotic Phosphorylation ATP Synthase: Top view: Hyper Text Books.

Online Biology Book. MIT Opencourseware: Biology. Brian E. Schultz, Sunney I. Chan. Structures and Proton-Pumping Strategies of Mitochondrial Respiratory Enzymes.

Annual Review of Biophysics and Biomolecular Structure30 (1). 1. Introduction. Complex I is a very large enzyme catalyzing at the entry point of the mitochondrial electron transport chain [1–3].The total number of subunits in the bovine heart enzyme is 45 [] for a molecular mass of about subunits are products of the mitochondrial genome [5,6] that correspond to hydrophobic subunits named ND1–ND6 and ND4 L.

1. Introduction. Complex I is a very large enzyme catalyzing at the entry point of the mitochondrial electron transport chain.The total number of subunits in the bovine heart enzyme is 45 for a molecular mass of about KDa.

Seven subunits are products of the mitochondrial genome, that correspond to hydrophobic subunits named ND1–ND6 and ND4 L.The oxygen reductases include the proton-pumping respiratory enzymes that terminate the aerobic respiratory chains in the mitochondrial inner membranes of eukaryotes as well as in the cytoplasmic.